Combine tequila, ½ cup red Skittles, and red food coloring in glass jar. Cover; let stand at room temperature overnight or until candies dissolve.

For margaritas, grind an additional ½ cup Skittles in blender. Rub rims of 2 (8-oz.) glasses with lime wedges. Dip rims in ground candies mixed with lime zest; set aside.

Add Skittle-infused tequila, Triple Sec, Rose's sweetened lime juice to an ice-filled cocktail shaker. Cover; shake until well-chilled. Strain into prepared glasses. Add ice; garnish with lime slices, if desired.